Failings of the primary literature
Ben Goldacre: What doctors don’t know about the drugs they prescribe:
Publication bias affects every field of medicine. About half of all trials, on average, go missing in action, and we know that positive findings are around twice as likely to be published as negative findings.
His description of the situation was a “disaster” is quite accurate. The business of primary journals combined with the business of funding studies, together they are letting us down.