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GATTACA is still pertinent 25 years later:

Through the lens of genetic exceptionalism, society often envisions genetic predictions as infallibly deterministic. Consider the demand for direct-to-consumer genomic technologies and the foresight consumers believe it will bring. In reality, much of genetics is inherently messy owing to, among other things, the complexity of polygenic risk profiles, especially in light of unknowable environmental considerations.

[GATTACA]’s warnings against allowing these statistical likelihoods to become self-fulfilling prophecies remain apropos. This is especially true for the increasingly pervasive ‘walking sick’ — those who underestimate their disease probabilities — and the ‘worried well’ (or, as the film refers to them, the ‘healthy ill’) — those who overestimate their statistical predispositions to future genetic conditions. Arguably, geneticists in their professional capacities can also sometimes seem to view genetic information as too deterministic. Even scientists can fail to fully appreciate the inexactness of many genetic predispositions, given penetrance, expressivity and external environmental factors that modulate the genetic information.

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In light of the continual encroachment of genetic surveillance on privacy, there is a growing dissatisfaction with the government’s use of genetic information. In particular, this past spring, a class action lawsuit was filed against the New York City Police Department for hosting a genetic database comprising samples from thousands of people who live in New York. According to the lawsuit, DNA was surreptitiously collected, without consent, from gum, drinks and cigarettes offered to those in police custody, including minors, regardless of their eventual guilt, and principally from minority communities. Problematically, the New York City Police Department’s database lacks the regulatory oversight of state and federal DNA databases. A similar lawsuit was filed in Orange County, California, the year before, about an even larger DNA database of the County District Attorney’s Office.

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I’ll be the first to agree with the spirit of George F. Will’s editorial about the historical importance of beer in the growth of urban populations (via Daring Fireball), but there are two issues in this piece of which the reader should be aware:

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She hung up the phone and I listened as, in a twist of irony, the dial-tone harmonized perfectly with George Winston’s “Living Without You” playing in the background. I listened until the tone stopped and the busy signal took over, beeping a relentless rhythm against my tired eardrums. I wondered if I would ever understand love, why it makes us do what we do, what it should be like, who are models of it, or even something as deceivingly simple as its definition.

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Michael Jackson. A Star Tribune review of a local opera. The musical group Barenaked Ladies. How could these topics be anything but non sequiturs in a stream-of-conscious rambling? I did not know either until about ten minutes ago. That’s when I decided to write this post instead of simply linking to the Star Tribune’s review of an opera about a man called the “Elephant Man.” He lived in the mid 1800s and had an extremely rare genetic disorder called “Proteus syndrome.” He is pictured at right. More on that picture in a second. You see, I was reading that opera review, and frankly could have cared less about the actual opera … I was fascinated about the real story of this man who was shunned from society and what disease he actually had. Towards the end, the review finally mentions this man, Joseph Merrick. It says he died simply by laying flat; the weight of his head broke his neck. It was three feet around at time of death.

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Meatiest cows … ever - Belgian blue cows don’t produce myostatin, which inhibits muscle development. So you end up with monster cows like this one. Interesting paper on myostatin.

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